The exact nature of the long-term effects of modafinil is not known. In addition, most of what we know about the drug refers to its official use as a treatment for narcolepsy. A pediatric Modafinil study used for narcolepsy found that no significant negative effects were seen during a very long-term period of patients (up to 10 years).
Long-term side effects and the benefits for its use as a cognitive enhancer are largely anecdotal. We know a number of short-term side effects, which are detailed in the next section. Or not any of these symptoms persist in chronic conditions especially is confusing, due to insufficient research.
From user reports in online forums, the following are some of the potential long-term negative reported effects of modafinil:
Headaches are the reported number one mild side effect of the use and order modafinil, with estimates of more than half of users experiencing headaches at some point. For the most part, these headaches are often quite mild and transient.
However, in some people, headaches never seem to go away or be better. While it can often be remedied with over-the-counter painkillers, this may not be an adequate long-term solution for everyone.
As discussed, modafinil is an alert and wakefulness promotion agent. While this is often good for reducing drowsiness, and improving productivity and concentration, it can lead to a sleep deprivation or a sleep deficit. Modafinil Report people do not feel like they need to sleep, even when they should. In these people, the desire to sleep is diminished, leading them to not sleep as much as they should.
This can lead some people to not getting enough sleep each night, it leads to a sleep debt, what is the cumulative effect of not getting enough sleep in the long term. This can have several physical and mental effects, such as amino acid imbalance, mood disorders, and increased stomach and mouth acidity, which can lead to dental problems.
While the exact mechanism of action of modafinil is unknown, it is known to interact with various neurotransmitters and their receptors and transports in the brain and central nervous system.
Long-term use of any psychoactive substance has the potential to change or alter normal homeostatic levels and functioning of neurotransmitters. Modafinil acts as a reuptake inhibitor of dopamine and norepinephrine, and prolonged use could lead to depleted stores or a deficiency of these compounds.
Modafinil is known to increase levels of Orexin and histamine, which could also lead to an exhaustion or eventual downregulation of endogenous production. Alternatively, if a user becomes tolerant to a smaller amount and continuously increases their dose, they could increase histamine levels, which can lead to an allergic reaction and allergy-like symptoms.
Some people who have been taking modafinil for a long time have reported the development of depression. This is probably due to the effects of Modafinil on several neurotransmitters, specifically the noradrenergic and dopaminergic transmission systems, however, this has not been studied or tested yet.
Dependence or tolerance
Two sides of the same coin, some people find that after they take modafinil for a long period of time they become dependent on its effects, while other people have reported that a tolerance developed and the medication does not work for them.
Some users have reported that after using Modafinil for a long time they need their effects for normal daily functioning. They say they feel they can not perform well in school or work and cannot maintain adequate levels of cognitive functioning. This dependence often happens after a while off the drug, but it can be difficult to adjust to many people.
As an anecdote, tolerance is an effect that develops in some people Use modafinil every day for years at a time. Their bodies become used to the amount of drug they take each day, and the benefits become less.
Some people will then increase their dose to try to regain the benefits that they experienced before, although this can lead to an increased risk of side effects. Modafinil cycling has been suggested in user reports as a way to avoid tolerance when using long-term modafinil.